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Home - Products - Metabolic Enzyme/Protease - P450 - NSC 207895

NSC 207895

CAS No. 58131-57-0

NSC 207895( —— )

Catalog No. M17547 CAS No. 58131-57-0

NSC 207895 suppresses MDMX with IC50 of 2.5 μM, leading to enhanced p53 stabilization/activation and DNA damage, and also regulates MDM2, an E3 ligase.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    NSC 207895
  • Note
    Research use only, not for human use.
  • Brief Description
    NSC 207895 suppresses MDMX with IC50 of 2.5 μM, leading to enhanced p53 stabilization/activation and DNA damage, and also regulates MDM2, an E3 ligase.
  • Description
    NSC 207895 suppresses MDMX with IC50 of 2.5 μM, leading to enhanced p53 stabilization/activation and DNA damage, and also regulates MDM2, an E3 ligase.
  • In Vitro
    Western Blot Analysis Cell Line:RAW 264.7 cells.Concentration:0.5 μM.Incubation Time:30 min (stimulated with LPS (100 ng/ml) for 6 h).Result:Upregulated p53 protein levels.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    P450
  • Recptor
    p53 , MDMX
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    58131-57-0
  • Formula Weight
    279.25
  • Molecular Formula
    C11H13N5O4
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 31.25 mg/mL (111.91 mM)
  • SMILES
    CN1CCN(CC1)C2=CC=C(C3=NO[N+](=C23)[O-])[N+](=O)[O-]
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Wang H, et al. Mol Cancer Ther, 2011, 10(1), 69-79.
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